More details about the secret of Viagra

Erectile dysfunction is defined as the persistent incapacity of achieving or maintaining an erection, which enables pleasurable sexual relations. Erectile dysfunction represents an exceptional burden for males and their partner. Epidemiological research has shown that 20% of males between the ages of 50 and 59 have difficulties in achieving an erection, afterwards the number of those affected in terms of age only sharply increases.

Sildenafil (Viagra) created a revolution in healing erectile dysfunction. Viagra itself does not cause an erection yet, it only functions as some kind of reinforcement as sexual arousal is needed beforehand. Viagra is a selective inhibitor of the enzyme fosodiesteraze-5. This enzyme is responsible for the decomposition of the molecule cGMP, which is located in smooth muscles of the male genitals. The final affect of Viagra is relaxing the smooth muscles and expanding the arteries, which causes an increased flow of blood into the genitals and his swollen erection.

Unfortunately, all males with erectile dysfunction do not respond the same to Viagra. Some research has shown that besides organic reasons, which could be agreed to for the unresponsiveness to the drug, it can also have an important role in small changes in the gene for GNB3 (G-protein beta 3 sub-unit). It is a polymorphism on the gene GNB3 or SNP rs5443. Smaller genetic research on 113 males with erectile dysfunction showed that 91% of males with the genotype rs5443 (T;T) had a satisfactory erection after taking Viagra, only 50% of the groups with the genotypes rs5443 (C;T) and rs5443 (C;C) had a positive response. Since it involved a relatively small research, additional research will be needed, which will confirm or reject the mentioned correlation.

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