More details about beta blockers and hight blood pressure

The effect of beta blockers depends on the structure of beta-receptors, which they have an impact on. The gene ADRB1 contains information on the structure beta-1 adrenergic receptor. Little variability in this gene or SNP in th elocation rs1801253 has significant impact on the effect of the beta blocker metoprol (Lopressor, Toprol-XL, Betaloc, Apo-Metoprol, Nu-Metop) on reducing diastolic blood pressure.

A smaller preliminary research on 40 patients, showed that metorprol has the strongest effect of reducing diastolic pressure in carriers with the gene type rs1801253(C;C) and has a significantly poorer effect on carriers with the gene type rs1801253(C;G).

Since the research was performed on a relatively small number of patients, it is necessary to confirm the results with a bigger group of hypertonics.

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