Glossary of terms

Association study - an overview of variations in the human genome with the aim of finding the genetic links to human diseases such as asthma, high blood pressure, etc. In order to figure out these links, the genomes of the disease-free individuals must be compared to the genomes of the people who have the disease. In both groups, SNPs are checked in the genomes in order to see if some SNPs appear more often in the diseased group than in the healthy group. If certain SNPs occur mainly in the patient group, it can be assumed that they are linked to the appearance of disease. The strength of this association is revealed by the result of the association study. We can use this association to also calculate the risk of the disease appearing in a random individual for whom we assume originates from the same population, given the SNPs in his genome and the incidence of disease in the population. The data of association studies, published in prestigious scientific journals, are used by the GenePlanet to calculate the risk of disease on the basis of personal genotyping.



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