Medicament response

The effect of medications and their side effects depends to a great degree on our genes. The genes determine the metabolic rate of the medications, their transport into the cells and organs, their excretion from the body and their effective binding sites.

Active substances act by binding to cellular proteins; otherwise there is no desired effect. However, DNA mutations affect structure of protein, responsible for drug effectiveness to differ between some individuals. This is reflected in the effect of particular drug. The effect may be lower than expected and the treatment is not successful. On the other side, the effect can be too strong which can lead to the side effects, that is, to the emergence of additional medical complications. When knowing someone’s genetic makeup, we can either properly adjust the dose, or we can replace the drug with alternative one.

The pharmaceutical companies have been planning a so-called personalized treatment. This approach will allow physicians to prescribe the dose or to choose appropriate drug according to individual’s genetic makeup. Every day we have more and more details about human genome, therefore, implementation of the trend described above is expected. This will prevent numerous side drug effects and/or will improve the effectiveness of drug therapy. Today, all this is a great benefit for quality of life.

Medicament response